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Safe GLP-1 tapering involves gradual dose reduction over 4–12 weeks under provider supervision, not abrupt discontinuation
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Although metformin increased GLP-1R level, exendin (9–39) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function