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Not all GLP-1–based therapies work the same way. Semaglutide targets the GLP -1 receptor, while tirzepatide targets both GLP-1 and GIP receptors. Retatrutide is being studied as a triple-receptor agonist targeting GLP-1, GIP
When caloric intake decreases, the body compensates by slowing metabolism and increasing hunger signals, making sustained weight loss difficult for many individuals
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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Lim R, Beekley A, Johnson DC, Davis KA
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